In St. Marks catholic boarding school for girls, the religious student Elizabeth is attacked by evil forces and disappears from the classroom and the impotent Father Drake is incapable of saving her. The school is closed and five years later it is reopened. Five troubled unwanted girls - Alex, Mara, the blind Cecilia, Leah and Connie - are left by their family in the institution, severely directed by the headmistress Miss Pearce with hands of iron. Father Drake is their teacher and the girls are forbidden to go to the mysterious third floor. When Alex has visions of the possessed Elizabeth, weird things happen in the spot and the girls have to fight against a legion of two thousand demons.

In Montreal, Joey is the lead singer of the struggling band "The Winners", composed by the sexy bass singer Jennifer, the guitarist Tyler, the drummer Sam and the handyman Hugo. Their incompetent and alcoholic manager Jeff is incapable to help them to reach success and they are on the road on tour playing in clubs and bars in Canada and United States of America. After a show in a bar in Montreal, Jennifer, who is also the Joey's former girlfriend, leaves the place with the creepy Queeny, who is a vampire, and they spend the night together. On the next morning, Jennifer does not meet the band and they travel in their hearse to participate in a rock 'n' roll show without her. In the last moment, Jennifer arrives with a different appearance and on the next day they find that their home page had had several hits, all of them with good reviews and compliments to Jennifer...